pregnancy outcome of chorionic villus sampling on 260 couples with beta- thalassemia trait in north of iran

نویسندگان

nesa asnafi department of gynecology, school of medicine, babol university of medical science, babol, iran.

haleh akhavan niaki genetic laboratory of amirkola children hospital and cellular and molecular biology research center, babol university of medical science, babol, iran.

چکیده

chorionic villus sampling (cvs) is a new method and its true risk of fetal loss and complications is not still clearly determined. the objective of this study was to review the clinical pregnancy outcome of transabdominal cvs (ta-cvs) performed on women with minor beta thalassemia. ta-cvs performed on 300 women with a singleton pregnancy and we could follow 213 women until delivery. data regarding induced legal abortion, spontaneous abortion, vaginal leakage, vaginal bleeding and deformity of extremities ( limb reduction) were obtained by questionnaire in five years. all cvs were performed by one operator. the mean gestation at time of cvs was 82.4±11.3 days. 79.2% of the procedures were made between 10-13 completed weeks and in other women (20.7%) ta-cvs was performed at 13-16 weeks. the majority (86.9%) required only one puncture. there were 47 pregnancy terminations because of fetal major beta thalassemia diagnosis (18 %). the rate of spontaneous abortion in our study was over ally (1.4%) and in two patients vaginal bleeding was noticed. we didn't find any vaginal leakage and limb reduction in our survey. ta-cvs is an accurate and safe procedure in experienced hands. it should be considered as one of the safe available procedures for women who require prenatal genetic diagnosis and wish to receive earlier diagnostic information for probable termination of pregnancy.

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منابع مشابه

Pregnancy outcome of chorionic villus sampling on 260 couples with beta-thalassemia trait in north of Iran.

Chorionic villus sampling (CVS) is a new method and its true risk of fetal loss and complications is not still clearly determined. The objective of this study was to review the clinical pregnancy outcome of transabdominal CVS (TA-CVS) performed on women with minor beta thalassemia. TA-CVS performed on 300 women with a singleton pregnancy and we could follow 213 women until delivery. Data regard...

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Chorionic villus sampling for the diagnosis of beta thalassemia in the first trimester of pregnancy in southwest Iran

Background and aim: Beta thalassemia is one of the most common hereditary disorders in Iran. The aim of this study is to improve the quality of life of couples with thalassemia and prenatal diagnosis of thalassemia major through the chorionic villus sampling technique. Methods: This prospective study was conducted on couples suffering from thalassemia minor who referred to Narges Genetics Labo...

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Chorionic Villus Sampling

Chorionic villus sampling (CVS) is a test used for prenatal diagnosis [5]. Safe to perform at an earlier stage in pregnancy [6] than amniocentesis, CVS is another invasive prenatal diagnostic test that can be performed as early as ten weeks after the woman?s last menstrual cycle. While this test does carry some risks, it is generally very effective at predicting heritable diseases during or soo...

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عنوان ژورنال:
acta medica iranica

جلد ۴۸، شماره ۳، صفحات ۱۶۸-۱۷۱

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